![I've compared the prototype E3 gamepad against the retail version. Nintendo did make some changes after the E3 in 2011 when they exhibited the console. : r/wiiu I've compared the prototype E3 gamepad against the retail version. Nintendo did make some changes after the E3 in 2011 when they exhibited the console. : r/wiiu](https://preview.redd.it/97xopzmxdlq61.jpg?width=640&crop=smart&auto=webp&s=a9107739553174eb728ecc6c243d5ff29c8c28e9)
I've compared the prototype E3 gamepad against the retail version. Nintendo did make some changes after the E3 in 2011 when they exhibited the console. : r/wiiu
![Genome-wide analysis of the U-box E3 ubiquitin ligase enzyme gene family in tomato | Scientific Reports Genome-wide analysis of the U-box E3 ubiquitin ligase enzyme gene family in tomato | Scientific Reports](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41598-020-66553-1/MediaObjects/41598_2020_66553_Fig1_HTML.png)
Genome-wide analysis of the U-box E3 ubiquitin ligase enzyme gene family in tomato | Scientific Reports
![PUB22 and PUB23 U-BOX E3 ligases directly ubiquitinate RPN6, a 26S proteasome lid subunit, for subsequent degradation in Arabidopsis thaliana - ScienceDirect PUB22 and PUB23 U-BOX E3 ligases directly ubiquitinate RPN6, a 26S proteasome lid subunit, for subsequent degradation in Arabidopsis thaliana - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006291X15302606-fx1.jpg)
PUB22 and PUB23 U-BOX E3 ligases directly ubiquitinate RPN6, a 26S proteasome lid subunit, for subsequent degradation in Arabidopsis thaliana - ScienceDirect
![A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants - ScienceDirect A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1097276517307050-fx1.jpg)
A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants - ScienceDirect
![Protein quality control: U-box-containing E3 ubiquitin ligases join the fold: Trends in Biochemical Sciences Protein quality control: U-box-containing E3 ubiquitin ligases join the fold: Trends in Biochemical Sciences](https://www.cell.com/cms/attachment/d570ddcf-3134-4d1a-a246-076e5a52db08/gr2.jpg)
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold: Trends in Biochemical Sciences
![Two types of E3 ligases, their interaction components, and their modes... | Download Scientific Diagram Two types of E3 ligases, their interaction components, and their modes... | Download Scientific Diagram](https://www.researchgate.net/publication/225090557/figure/fig1/AS:269697144848384@1441312218722/Two-types-of-E3-ligases-their-interaction-components-and-their-modes-of-action.png)
Two types of E3 ligases, their interaction components, and their modes... | Download Scientific Diagram
![The classification of E3 ubiquitin ligases. E3 ubiquitin ligases are... | Download Scientific Diagram The classification of E3 ubiquitin ligases. E3 ubiquitin ligases are... | Download Scientific Diagram](https://www.researchgate.net/publication/361920313/figure/fig2/AS:1182632637403189@1658973001854/The-classification-of-E3-ubiquitin-ligases-E3-ubiquitin-ligases-are-classified-as-the.png)
The classification of E3 ubiquitin ligases. E3 ubiquitin ligases are... | Download Scientific Diagram
![Genome-wide analysis of the U-box E3 ubiquitin ligase enzyme gene family in tomato | Scientific Reports Genome-wide analysis of the U-box E3 ubiquitin ligase enzyme gene family in tomato | Scientific Reports](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41598-020-66553-1/MediaObjects/41598_2020_66553_Fig3_HTML.png)
Genome-wide analysis of the U-box E3 ubiquitin ligase enzyme gene family in tomato | Scientific Reports
![Protein quality control: U-box-containing E3 ubiquitin ligases join the fold: Trends in Biochemical Sciences Protein quality control: U-box-containing E3 ubiquitin ligases join the fold: Trends in Biochemical Sciences](https://www.cell.com/cms/attachment/556513/3982472/gr1.jpg)